Flumazenil—Treatment or Toxin

  title={Flumazenil—Treatment or Toxin},
  author={Donna L. Seger},
  journal={Journal of Toxicology: Clinical Toxicology},
  pages={209 - 216}
  • D. Seger
  • Published 1 January 2004
  • Medicine
  • Journal of Toxicology: Clinical Toxicology
Flumazenil is frequently administered to the poisoned patient. Seizures may be precipitated and resedation may occur in patients who awakened following flumazenil administration. Seizures may increase morbidity and mortality of the overdose. Benefit: Risk ratio of administering flumazenil should be determined in each overdose patient. Indications for flumazenil are limited. 
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Seizure after flumazenil administration in a pediatric patient.
The occurrence of a generalized tonic-clonic seizure in a pediatric patient following the administration of flumazenil is reported.
Flumazenil (Anexate) in severe intoxication with carbamazepine (Tegretol).
In addition to the benzodiazepine antagonism, the effect of flumazenil on carbamazepine intoxication is reported, as a first observation, where a mechanism other than benzodiazine receptor antagonism must be supposed.
Seizures after flumazenil administration in a case of combined benzodiazepine and tricyclic antidepressant overdose.
Flumazenil (Anexate®, Roche, Basel, Switzerland) is a specific, high-affinity, competitive inhibitor of the central nervous system's benzodiazepine γ-aminobutyric acid receptor, with high clinical
Flumazenil associated seizure in an 11-month-old child.
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This observation is the first report of drug poisoning with zolpidem, which was characterized by the development of a profound but short-lasting coma, associated with pin-point pupils and respiratory depression, as observed in a narcotic overdose.
Response of a promethazine-induced coma to flumazenil.
Flumazenil reversal of carisoprodol (Soma) intoxication.
Flumazenil and seizures: analysis of 43 cases.
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To minimize the likelihood of a seizure, it is recommended that flumazenil not be administered to patients who have used benzodiazepines for the treatment of seizure disorders or to patientsWho have ingested drugs that place them at risk for the development of seizures.
Fatal Seizures after Flumazenil Administration in a Patient with Mixed Overdose
Flumazenil should be used with caution in patients with chronic benzodiazepine use, prior seizure history, or when a mixed overdose is suspected, as it may unmask tricyclic antidepressant—induced seizures by antagonizing the antiepileptic effect of concomitantly ingested benzdiazepine.
Empiric use of flumazenil in comatose patients: limited applicability of criteria to define low risk.