Fluid shear stress stimulates mitogen-activated protein kinase in endothelial cells.

@article{Tseng1995FluidSS,
  title={Fluid shear stress stimulates mitogen-activated protein kinase in endothelial cells.},
  author={Hung Tseng and Timothy E. Peterson and Bradford C. Berk},
  journal={Circulation research},
  year={1995},
  volume={77 5},
  pages={869-78}
}
Local alterations in the hemodynamic environment regulate endothelial cell function, but the signal-transduction mechanisms involved in this process remain unclear. Because mitogen-activated protein (MAP) kinases have been shown to be activated by physical forces, we measured the phosphorylation and enzyme activity of MAP kinase to identify the signal events involved in the endothelial cell response to fluid shear stress. Flow at physiological shear stress (3.5 to 117 dynes/cm2) activated 42-kD… CONTINUE READING

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