Fluid shear stress regulates the expression of Lectin-like oxidized low density lipoprotein receptor-1 via KLF2-AP-1 pathway depending on its intensity and pattern in endothelial cells.

@article{Lee2018FluidSS,
  title={Fluid shear stress regulates the expression of Lectin-like oxidized low density lipoprotein receptor-1 via KLF2-AP-1 pathway depending on its intensity and pattern in endothelial cells.},
  author={Ji Yoon Lee and Jihwa Chung and Kyoung Hwa Kim and Shung Hyun An and Minsuk Kim and Junbeom Park and Kihwan Kwon},
  journal={Atherosclerosis},
  year={2018},
  volume={270},
  pages={76-88}
}
BACKGROUND AND AIMS Vascular endothelial cells (ECs) are exposed to fluid shear stress (FSS), which modulates vascular pathophysiology. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is crucial in endothelial dysfunction and atherosclerosis. We elucidated the mechanism regulating LOX-1 expression in ECs by FSS. METHODS Human umbilical… CONTINUE READING