Fluid shear stress modulates endothelial cell invasion into three-dimensional collagen matrices.

@article{Kang2008FluidSS,
  title={Fluid shear stress modulates endothelial cell invasion into three-dimensional collagen matrices.},
  author={Hojin Kang and Kayla J. Bayless and Roland R. Kaunas},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2008},
  volume={295 5},
  pages={H2087-97}
}
Endothelial cells are subjected to biochemical and mechanical stimuli, which regulate their angiogenic potential. We determined the synergistic effects of sphingosine-1-phosphate (S1P) and fluid wall shear stress (WSS) on a previously established model of human umbilical vein endothelial cell invasion into three-dimensional collagen matrices. Collagen matrices were incorporated into a parallel-plate flow chamber to apply controlled WSS to the surface of endothelial monolayers over a period of… CONTINUE READING