Fluid shear stress inhibits vascular inflammation by decreasing thioredoxin-interacting protein in endothelial cells.

@article{Yamawaki2005FluidSS,
  title={Fluid shear stress inhibits vascular inflammation by decreasing thioredoxin-interacting protein in endothelial cells.},
  author={Hideyuki Yamawaki and Shi Pan and Richard T Lee and Bradford C. Berk},
  journal={The Journal of clinical investigation},
  year={2005},
  volume={115 3},
  pages={733-8}
}
Regions in the vasculature that are exposed to steady laminar blood flow are protected from atherosclerosis as compared with regions where flow is disturbed. We found that flow decreased TNF-mediated VCAM1 expression by inhibiting JNK and p38. JNK inhibition correlated with inhibition of apoptosis signal-regulating kinase 1 (ASK1), a JNK and p38 activator. Thioredoxin-interacting protein (TXNIP) is a stress-responsive protein that inhibits thioredoxin (TRX) activity. Since thioredoxin inhibits… CONTINUE READING