Fluid shear stress induction of the transcriptional activator c-fos in human and bovine endothelial cells, HeLa, and Chinese hamster ovary cells.

@article{Ranjan1996FluidSS,
  title={Fluid shear stress induction of the transcriptional activator c-fos in human and bovine endothelial cells, HeLa, and Chinese hamster ovary cells.},
  author={Vaibhav Ranjan and R G Waterbury and Zeshuai Xiao and Scott L. Diamond},
  journal={Biotechnology and bioengineering},
  year={1996},
  volume={49 4},
  pages={383-90}
}
The c-fos protein belongs to a family of transcriptional cofactors that can complex with proteins of the Jun family and activate mRNA transcription from gene promoters containing an activator protein 1 (AP-1) binding element. The shear stress inducibility of the c-fos protein was studied in human and animal cell lines of vastly different origins. Primary human umbilical vein endothelial cells (HUVEC), bovine aortic endothelial cells (BAEC, passage 2-14), HeLa cells, and Chinese hamster ovary… CONTINUE READING