Fluid shear stress-induced cyclooxygenase-2 expression is mediated by C/EBP beta, cAMP-response element-binding protein, and AP-1 in osteoblastic MC3T3-E1 cells.

@article{Ogasawara2001FluidSS,
  title={Fluid shear stress-induced cyclooxygenase-2 expression is mediated by C/EBP beta, cAMP-response element-binding protein, and AP-1 in osteoblastic MC3T3-E1 cells.},
  author={Asuka Ogasawara and Toshiya Arakawa and Toshio Kaneda and Taishin Takuma and Takuya Sato and Hironori Kaneko and Masayoshi Kumegawa and Yoshiyuki Hakeda},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 10},
  pages={7048-54}
}
Mechanical loading is crucial for maintenance of bone integrity and architecture, and prostaglandins are an important mediator of mechanosensing. Cyclooxygenase-2 (COX-2), an inducible isoform of prostaglandin G/H synthase, is induced by mechanical loading-derived fluid shear stress in bone-forming cells such as osteoblasts and osteocytes. In this study, we investigated transcription factor and transcriptional regulatory elements responsible for the shear stress-induced COX-2 expression in… CONTINUE READING

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