Fluid shear stress-induced JNK activity leads to actin remodeling for cell alignment.

@article{Mengistu2011FluidSS,
  title={Fluid shear stress-induced JNK activity leads to actin remodeling for cell alignment.},
  author={Meron Mengistu and Hannah Brotzman and Samir N Ghadiali and Linda J. Lowe-Krentz},
  journal={Journal of cellular physiology},
  year={2011},
  volume={226 1},
  pages={110-21}
}
Fluid shear stress (FSS) exerted on endothelial cell (EC) surfaces induces actin cytoskeleton remodeling through mechanotransduction. This study was designed to determine whether FSS activates Jun N-terminal kinase (JNK), to examine the spatial and temporal distribution of active JNK relative to the actin cytoskeleton in ECs exposed to different FSS conditions, and to evaluate the effects of active JNK on actin realignment. Exposure to 15 and 20 dyn/cm(2) FSS induced higher activity levels of… CONTINUE READING

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