Fluid shear-induced NFkappaB translocation in osteoblasts is mediated by intracellular calcium release.

@article{Chen2003FluidSN,
  title={Fluid shear-induced NFkappaB translocation in osteoblasts is mediated by intracellular calcium release.},
  author={Neal X. Chen and Derik J. Geist and Damian Christopher Genetos and Fredrick M. Pavalko and Randall L. Duncan},
  journal={Bone},
  year={2003},
  volume={33 3},
  pages={399-410}
}
Bone formation in response to exogenous mechanical loading is dependent on prostaglandin synthesis by the inducible isoform of cyclooxygenase, COX-2. While several transcription factors target the COX-2 gene, we examined the role of nuclear factor kappa B (NFkappaB) on COX-2 upregulation in osteoblasts in response to fluid shear due to its involvement in immune and inflammatory responses in other cell types. Application of 12 dyn/cm2 laminar flow to MC3T3-E1 osteoblast-like cells resulted in… CONTINUE READING

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