Fluid resuscitation influences cardiovascular performance and mortality in a murine model of sepsis

@article{ZanottiCavazzoni2008FluidRI,
  title={Fluid resuscitation influences cardiovascular performance and mortality in a murine model of sepsis},
  author={Sergio L. Zanotti-Cavazzoni and Massimiliano Guglielmi and Joseph E. Parrillo and Tracy Walker and Richard Phillip Dellinger and Steven M. Hollenberg},
  journal={Intensive Care Medicine},
  year={2008},
  volume={35},
  pages={748-754}
}
Current murine models of sepsis do not account for the effects of aggressive fluid resuscitation on hemodynamics and mortality. Evaluate the impact of fluid resuscitation regimens on cardiovascular performance and survival in a murine model of sepsis. Mice (n = 90) were made septic by cecal ligation and puncture (CLP), and received antibiotics plus Low, Intermediate, or High fluid resuscitation regimens. Stroke volume (SV), cardiac output (CO), and fractional shortening (FS) were measured by… CONTINUE READING