Fluid resuscitation increases inflammatory gene transcription after traumatic injury.

@article{Watters2006FluidRI,
  title={Fluid resuscitation increases inflammatory gene transcription after traumatic injury.},
  author={Jennifer M. Watters and Brandon Tieu and Samuel R Todd and Terisa Jackson and Patrick J Muller and Darren Jay Malinoski and Martin Schreiber},
  journal={The Journal of trauma},
  year={2006},
  volume={61 2},
  pages={300-8; discussion 308-9}
}
BACKGROUND The debate continues over type and quantity of fluid to administer for resuscitation after traumatic injury. This study aimed to examine effects of resuscitation with lactated Ringer's (LR) and Hextend (HEX) on the inflammatory response after uncontrolled hemorrhagic shock (UHS). METHODS There were 38 swine randomized. Control swine were anesthetized and killed. Sham swine underwent laparotomy, splenectomy, and 2 hours of anesthesia. UHS swine received a grade V liver injury after… CONTINUE READING

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Lung tissue mRNA levels of interleukin-6 ( IL-6 ) , granulocyte colony stimulating factor ( G - CSF ) , and tumor necrosis factor alpha ( TNF - alpha ) were determined .
UHS swine received a grade V liver injury after laparotomy and splenectomy and were randomized to no fluid ( NF ) resuscitation or to blinded resuscitation 30 minutes after injury with LR or HEX .
Sham swine underwent laparotomy , splenectomy , and 2 hours of anesthesia .
UHS swine received a grade V liver injury after laparotomy and splenectomy and were randomized to no fluid ( NF ) resuscitation or to blinded resuscitation 30 minutes after injury with LR or HEX .
Sham swine underwent laparotomy , splenectomy , and 2 hours of anesthesia .
Lung tissue mRNA levels of interleukin-6 ( IL-6 ) , granulocyte colony stimulating factor ( G - CSF ) , and tumor necrosis factor alpha ( TNF - alpha ) were determined .
Lung tissue mRNA levels of interleukin-6 ( IL-6 ) , granulocyte colony stimulating factor ( G - CSF ) , and tumor necrosis factor alpha ( TNF - alpha ) were determined .
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