Fluid overload, de-resuscitation, and outcomes in critically ill or injured patients: a systematic review with suggestions for clinical practice.

@article{Malbrain2014FluidOD,
  title={Fluid overload, de-resuscitation, and outcomes in critically ill or injured patients: a systematic review with suggestions for clinical practice.},
  author={Manu L. N. G. Malbrain and Paul Ellis Marik and Ine Witters and Colin Cordemans and Andrew W Kirkpatrick and Derek J. Roberts and Niels Van Regenmortel},
  journal={Anaesthesiology intensive therapy},
  year={2014},
  volume={46 5},
  pages={361-80}
}
BACKGROUND Sepsis is associated with generalised endothelial injury and capillary leak and has traditionally been treated with large volume fluid resuscitation. Some patients with sepsis will accumulate bodily fluids. The aim of this study was to systematically review the association between a positive fluid balance/fluid overload and outcomes in critically ill adults, and to determine whether interventions aimed at reducing fluid balance may be linked with improved outcomes. METHODS We… CONTINUE READING
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