Fluid loss does not explain coagulation activation during air travel.

@article{Schreijer2008FluidLD,
  title={Fluid loss does not explain coagulation activation during air travel.},
  author={Anja J. M. Schreijer and Suzanne C. Cannegieter and Marianna Caramella and Joost C. M. Meijers and Raymond T Krediet and Ries M Simons and Frits Richard Rosendaal},
  journal={Thrombosis and haemostasis},
  year={2008},
  volume={99 6},
  pages={
          1053-9
        }
}
The mechanism of air travel-related venous thrombosis is unclear. Although immobility plays a pivotal role, other factors such as fluid loss may contribute. We investigated whether fluid loss occurred more in individuals with coagulation activation after air travel than in subjects without. As a secondary aim, we investigated whether fluid loss per se occurred during air travel. In this crossover study, 71 healthy volunteers were exposed to eight hours of air travel, eight hours immobilization… 

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References

SHOWING 1-10 OF 35 REFERENCES
Coagulation changes and edema formation during long-distance bus travel
TLDR
It is concluded that beside long-haul flights also long-distance bus travel induces a certain activation of the coagulation system, and it is questionable whether hypoxia is the crucial risk factor for thromboembolic events after long- haul flights.
Air travel and thrombosis
TLDR
The current literature suggests a weak association between long‐distance travel and the development of asymptomatic venous thromboembolism (VTE) and, given the plausible risk‐free benefit, all passengers should be advised to maintain adequate hydration and exercise.
The influence of a prolonged sitting position on the biochemical markers of coagulation activation in healthy subjects: evidence of reduced thrombin generation
TLDR
The data suggest that subclinical thrombosis may be frequent during air travel but usually resolves once mobility is resumed, and the hypothesis that prolonged immobility in a sitting position similar to the one occurring during air traveling activates coagulation is tested.
Economy class syndrome: rheology, fluid balance, and lower leg edema during a simulated 12-hour long distance flight.
In order to study pathological changes that might lead to deep vein thrombosis and pulmonary embolism in long-distance air travel passengers, 12 healthy volunteers were investigated during 4
Human coagulation abnormalities during acute exposure to hypobaric hypoxia.
TLDR
Although normal platelet function did not appear to be modified by short-term exposure to simulated high altitude, evidence for a coagulopathy was obtained.
Formation of edema and fluid shifts during a long-haul flight.
TLDR
It is demonstrated that long-haul flights induce significant fluid accumulation in the lower extremity, involving the lower leg and thigh, and this increase in tissue thickness was maintained for some days after the flights.
Dehydration and venous thromboembolism after acute stroke.
TLDR
Dehydration after AIS is strongly independently associated with VTE, reinforcing the importance of maintaining adequate hydration in these patients, and the relationship between biochemical indices of dehydration and VTE after acute ischaemic stroke is evaluated.
...
1
2
3
4
...