Fluid flow stimulates rapid and continuous release of nitric oxide in osteoblasts.

@article{Johnson1996FluidFS,
  title={Fluid flow stimulates rapid and continuous release of nitric oxide in osteoblasts.},
  author={Dr. Mary Lynn Johnson and T N McAllister and John A. Frangos},
  journal={The American journal of physiology},
  year={1996},
  volume={271 1 Pt 1},
  pages={E205-8}
}
Interstitial fluid flow may mediate skeletal remodeling in response to mechanical loading. Because nitric oxide (NO) has been shown to be an osteoblast mitogen and inhibitor of osteoclastic resorption, we investigated and characterized the role of fluid shear on the release of NO in osteoblasts. Rat calvarial cells in a stationary culture produced undetectable levels of NO. Fluid shear stress (6 dyn/cm2) rapidly increased NO release rate to 9.8 nmol.h-1.mg protein-1 and sustained this… CONTINUE READING
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