Fluid flow inhibits endothelial adhesiveness. Nitric oxide and transcriptional regulation of VCAM-1.

@article{Tsao1996FluidFI,
  title={Fluid flow inhibits endothelial adhesiveness. Nitric oxide and transcriptional regulation of VCAM-1.},
  author={Philip S. Tsao and Robison Buitrago and Jason R. Chan and John P Cooke},
  journal={Circulation},
  year={1996},
  volume={94 7},
  pages={1682-9}
}
BACKGROUND In the arterial tree, regions exposed to reduced shear stress (low and/or disturbed flow) are predisposed to atherogenesis. Fluid flow is a potent stimulus for the release of endothelium-derived nitric oxide (NO). Because NO inhibits monocyte-endothelial cell interaction, we speculated that the effects of flow in inhibiting atherogenesis might be mediated in part by NO. METHODS AND RESULTS Confluent monolayers of human aortic endothelial cells were exposed to static or fluid flow… CONTINUE READING
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