Fluid flow-induced soluble vascular endothelial growth factor isoforms regulate actin adaptation in osteoblasts.

@article{Thi2010FluidFS,
  title={Fluid flow-induced soluble vascular endothelial growth factor isoforms regulate actin adaptation in osteoblasts.},
  author={Mia M. Thi and Sylvia Ottilie Suadicani and David Conover Spray},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 40},
  pages={30931-41}
}
Although load-induced mechanical signals play a key role in bone formation and maintenance of bone mass and structure, the cellular mechanisms involved in the translation of these signals are still not well understood. Recent identification of a novel flow-induced mechanosignaling pathway involving VEGF in osteoblasts and the known VEGF regulation of actin reorganization in various cell types has led us to hypothesize that fluid shear stress-induced Vegf up-regulation underlies the actin… CONTINUE READING
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Flow-induced VEGF Regulates Actin Adaptation in Osteoblasts

  • M. Milkiewicz, J. L. Doyle, T. Fudalewski, E. Ispanovic, M. Aghasi, T. L. Haas
  • J. Physiol. 583,
  • 2007

VEGF and Development (Ruhrberg

  • C. Maes, G. Carmeliet
  • C., ed)
  • 2007

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