Fluid flow in the sarcomere.

@article{Malingen2021FluidFI,
  title={Fluid flow in the sarcomere.},
  author={Sage A. Malingen and Kaitlyn Hood and Eric Lauga and Anette Hosoi and Thomas L. Daniel},
  journal={Archives of biochemistry and biophysics},
  year={2021},
  pages={
          108923
        }
}

Figures and Tables from this paper

Active muscular hydraulics

TLDR
A minimal multiscale model of muscle dynamics is proposed that describes muscle as an active sponge and it is shown how contractions generically induce intracellular fluid flow and power active hydraulic oscillations which dictate the fastest rate of muscle contraction.

References

SHOWING 1-10 OF 50 REFERENCES

A mechanism for sarcomere breathing: volume change and advective flow within the myofilament lattice.

A mathematical analysis of obstructed diffusion within skeletal muscle.

The filament lattice of striated muscle.

TLDR
The effects of lattice change on muscle contraction in vertebrate skeletal and cardiac muscle and in invertebrate striated muscle are reviewed and the force developed, the speed of shortening, and stiffness are compared with structural changes occurring within the lattice.

The Sliding Filament Theory Since Andrew Huxley: Multiscale and Multidisciplinary Muscle Research.

TLDR
Current and historical research in muscle physiology sparked by the sliding filament theory is reviewed and structural and functional properties that are relevant at one spatiotemporal scale to those that arerelevant at other scales remains a great challenge.

Muscle contraction: viscous-like frictional forces and the impulsive model.

Atomic model of a myosin filament in the relaxed state

TLDR
Three-dimensional reconstruction and atomic fitting studies suggest that the ‘interacting-head’ structure is also present in the filament, and that it may underlie the relaxed state of thick filaments in both smooth and myosin-regulated striated muscles over a wide range of species.

Architecture and function in the muscle sarcomere.

  • J. Squire
  • Biology, Chemistry
    Current opinion in structural biology
  • 1997

Three-dimensional structure of the basketweave Z-band in midshipman fish sonic muscle

TLDR
The Z-band model provides a detailed understanding of the role of α-actinin in transmitting tension between actin filaments in adjoining sarcomeres and the basketweave form occurs in certain relaxed muscles as in the muscle studied here.

The cytoplasm of living cells behaves as a poroelastic material

TLDR
The poroelastic model is directly validated to explain cellular rheology at physiologically relevant timescales using microindentation tests in conjunction with mechanical, chemical and genetic treatments and shows that water redistribution through the solid phase of the cytoplasm (cytoskeleton and macromolecular crowders) plays a fundamental role in setting cellularRheology.

Intracellular Fluid Mechanics: Coupling Cytoplasmic Flow with Active Cytoskeletal Gel

The cell is a mechanical machine, and continuum mechanics of the fluid cytoplasm and the viscoelastic deforming cytoskeleton play key roles in cell physiology. We review mathematical models of