Fluid dynamics alter Caenorhabditis elegans body length via TGF-β/DBL-1 neuromuscular signaling

@inproceedings{Harada2016FluidDA,
  title={Fluid dynamics alter Caenorhabditis elegans body length via TGF-β/DBL-1 neuromuscular signaling},
  author={Shunsuke Harada and Toko Hashizume and Kanako Nemoto and Zhenhua Shao and Nahoko Higashitani and Timothy Etheridge and Nathaniel J Szewczyk and Keiji Fukui and Akira Higashibata and Atsushi Higashitani},
  booktitle={npj Microgravity},
  year={2016}
}
Skeletal muscle wasting is a major obstacle for long-term space exploration. Similar to astronauts, the nematode Caenorhabditis elegans displays negative muscular and physical effects when in microgravity in space. It remains unclear what signaling molecules and behavior(s) cause these negative alterations. Here we studied key signaling molecules involved in alterations of C. elegans physique in response to fluid dynamics in ground-based experiments. Placing worms in space on a 1G accelerator… CONTINUE READING
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SHOWING 1-10 OF 46 REFERENCES

Caenorhabditis elegans selects distinct crawling and swimming gaits via dopamine and serotonin.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2011
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

The effectiveness of RNAi in Caenorhabditis elegans is maintained during spaceflight

T Etheridge
  • PLoS One 6,
  • 2011
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Comparison and reproducibility of sEMG during manual muscle testing on land and in water.

  • Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology
  • 2011

Biomechanical analysis of gait adaptation in the nematode Caenorhabditis elegans

C Fang-Yen
  • Proc. Natl Acad. Sci. USA
  • 2010
VIEW 2 EXCERPTS

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