Fluid consumption in water-deprived rats after administration of naloxone or quaternary naloxone.

@article{Turkish1983FluidCI,
  title={Fluid consumption in water-deprived rats after administration of naloxone or quaternary naloxone.},
  author={S. Turkish and S J Cooper},
  journal={Progress in neuro-psychopharmacology & biological psychiatry},
  year={1983},
  volume={7 4-6},
  pages={835-9}
}
Water-deprived male rats were given access to water, or to a 0.005M sodium saccharin solution, or to a 0.9% sodium chloride solution, during a 30 min test period. Naloxone (0.01-10.0 mg/kg) produced dose-dependent reductions in the consumption of each fluid. Saccharin-drinking was significantly reduced by 0.01 mg/kg naloxone, and water- and saline-drinking by 0.1 mg/kg naloxone. Quaternary naloxone (0.01-10.0 mg/kg) had no effect on drinking under any condition. Access to the saline solution… CONTINUE READING