Fluid Shear Stress Differentially Regulates gpr3, gpr6, and gpr12 Expression in Human Umbilical Vein Endothelial Cells

@article{Uhlenbrock2003FluidSS,
  title={Fluid Shear Stress Differentially Regulates gpr3, gpr6, and gpr12 Expression in Human Umbilical Vein Endothelial Cells},
  author={Kirsten Uhlenbrock and Jochen Huber and Ali Ardati and Andreas E. Busch and Evi Kostenis},
  journal={Cellular Physiology and Biochemistry},
  year={2003},
  volume={13},
  pages={75 - 84}
}
Fluid shear stress is a major factor involved in the control of gene expression in vascular endothelial cells. Sphingosine 1-phosphate has emerged as a multifaceted regulator of endothelial cell function and its high affinity S1P1 receptor is one among the many shear stress regulated genes. We recently identified the orphan G protein coupled receptors gpr3, gpr6 and gpr12 as additional S1P receptors. Here, we investigated their expression in various human endothelial and vascular smooth muscle… 

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