Fluid Mechanical Forces and Endothelial Mitochondria: A Bioengineering Perspective.

@article{Scheitlin2014FluidMF,
  title={Fluid Mechanical Forces and Endothelial Mitochondria: A Bioengineering Perspective.},
  author={Christopher Gordon Scheitlin and Devi M Nair and Juan A. Crestanello and Jay L. Zweier and B Rita Alevriadou},
  journal={Cellular and molecular bioengineering},
  year={2014},
  volume={7 4},
  pages={
          483-496
        }
}
Endothelial cell dysfunction is the hallmark of every cardiovascular disease/condition, including atherosclerosis and ischemia/reperfusion injury. Fluid shear stress acting on the vascular endothelium is known to regulate cell homeostasis. Altered hemodynamics is thought to play a causative role in endothelial dysfunction. The dysfunction is associated with/preceded by mitochondrial oxidative stress. Studies by our group and others have shown that the form and/or function of the mitochondrial… CONTINUE READING
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