Flufenamic acid suppresses epileptiform activity in hippocampus by reducing excitatory synaptic transmission and neuronal excitability.

@article{Fernndez2010FlufenamicAS,
  title={Flufenamic acid suppresses epileptiform activity in hippocampus by reducing excitatory synaptic transmission and neuronal excitability.},
  author={Miriam Fern{\'a}ndez and Cristina Lao-Peregr{\'i}n and Eduardo D. Mart{\'i}n},
  journal={Epilepsia},
  year={2010},
  volume={51 3},
  pages={384-90}
}
PURPOSE In this study, we explore the antiepileptic effects of flufenamic acid (FFA) in order to identify the cellular mechanisms that underlie the potential anticonvulsant properties of this nonsteroidal antiinflammatory compound. METHODS The mechanisms of FFA action were analyzed using an in vitro model in which epileptiform activity was induced in hippocampal slices by perfusion with 100 microm 4-aminopyridine (4-AP) added to a modified Mg(2+)-free solution. The activity of CA1 pyramidal… CONTINUE READING