Flufenamic acid as an ion channel modulator.

@article{Guinamard2013FlufenamicAA,
  title={Flufenamic acid as an ion channel modulator.},
  author={Romain Guinamard and Christophe Simard and Christopher A. Del Negro},
  journal={Pharmacology & therapeutics},
  year={2013},
  volume={138 2},
  pages={
          272-84
        }
}
  • Romain Guinamard, Christophe Simard, Christopher A. Del Negro
  • Published 2013
  • Medicine, Chemistry
  • Pharmacology & therapeutics
  • Flufenamic acid has been known since the 1960s to have anti-inflammatory properties attributable to the reduction of prostaglandin synthesis. Thirty years later, flufenamic acid appeared to be an ion channel modulator. Thus, while its use in medicine diminished, its use in ionic channel research expanded. Flufenamic acid commonly not only affects non-selective cation channels and chloride channels, but also modulates potassium, calcium and sodium channels with effective concentrations ranging… CONTINUE READING

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    References

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    Nonsteroidal Anti-Inflammatory Drug Flufenamic Acid Is a Potent Activator of AMP-Activated Protein Kinase

    • Yuan Chi, Kai Li, +8 authors Jian Yao
    • Medicine, Chemistry
    • Journal of Pharmacology and Experimental Therapeutics
    • 2011
    VIEW 1 EXCERPT

    Fenamates as TRP channel blockers: mefenamic acid selectively blocks TRPM3.

    VIEW 5 EXCERPTS
    HIGHLY INFLUENTIAL

    Effect of non-steroidal anti-inflammatory drugs and new fenamate analogues on TRPC4 and TRPC5 channels.

    VIEW 2 EXCERPTS
    HIGHLY INFLUENTIAL