Fludarabine plus cyclophosphamide is an efficient treatment for advanced chronic lymphocytic leukaemia (CLL): results of a phase II study of the German CLL Study Group.

@article{Hallek2001FludarabinePC,
  title={Fludarabine plus cyclophosphamide is an efficient treatment for advanced chronic lymphocytic leukaemia (CLL): results of a phase II study of the German CLL Study Group.},
  author={Michael J Hallek and Barbara A Schmitt and M. Wilhelm and Raymonde M Busch and Alexander Kroeber and H P Fostitsch and Orhan Sezer and Michael Herold and Wolfgang Ulrich Knauf and Clemens Martin Wendtner and Rolf Kuse and Mathias Freund and Astrid Franke and Folke Schriever and Christoph Nerl and Hartmut D{\"o}hner and Eckhard Thiel and Wolfgang Hiddemann and G{\"u}nter Brittinger and Berthold Emmerich},
  journal={British journal of haematology},
  year={2001},
  volume={114 2},
  pages={342-8}
}
The efficacy and toxicity of a combination of fludarabine and cyclophosphamide (FC) was evaluated in patients with B-cell chronic lymphocytic leukaemia (CLL). Between April 1997 and July 1998, 36 patients with CLL (median age 59 years) received a regimen that consisted of fludarabine 30 mg/m(2) in a 30-min IV infusion, d 1-3, and cyclophosphamide 250 mg/m(2) in a 30-min IV infusion on d 1-3. Cycles were repeated every 28 d. Twenty-one patients had received between one and three different… CONTINUE READING