Fludarabine phosphate and melphalan: a reduced intensity conditioning regimen suitable for allogeneic transplantation that maintains the graft versus malignancy effect

@article{Dasgupta2006FludarabinePA,
  title={Fludarabine phosphate and melphalan: a reduced intensity conditioning regimen suitable for allogeneic transplantation that maintains the graft versus malignancy effect},
  author={Ranjit K. Dasgupta and S. Rule and P Johnson and John Davies and A J Burnett and Christopher Poynton and Kathy S Wilson and Graeme Murray Smith and G K Jackson and Charlotte Richardson and E Wareham and A C Stars and Sall Tollerfield and Gareth J Morgan},
  journal={Bone Marrow Transplantation},
  year={2006},
  volume={37},
  pages={455-461}
}
Reduced intensity conditioning (RIC) for allogeneic stem cell transplantation allows stable donor cell engraftment with the maintenance of a graft versus malignancy effect. Many different regimens exist employing various combinations of chemotherapy, radiotherapy and T-cell depletion. We examined the role of non-T-cell depleted RIC regimens in 56 patients with haematological malignancies. Patients received fludarabine phosphate for 5 days (30 mg/m2 in 35 patients, 25 mg/m2 in 21 patients) and… CONTINUE READING

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with reducedintensity conditioning : results from the Spanish multicenter prospective trial

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  • Bone Marrow Transplant
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