Fludarabine infusion potentiates arabinosylcytosine metabolism in lymphocytes of patients with chronic lymphocytic leukemia.

@article{Gandhi1992FludarabineIP,
  title={Fludarabine infusion potentiates arabinosylcytosine metabolism in lymphocytes of patients with chronic lymphocytic leukemia.},
  author={V Gandhi and Annette Kemena and M J Keating and W Plunkett},
  journal={Cancer research},
  year={1992},
  volume={52 4},
  pages={897-903}
}
  • V Gandhi, Annette Kemena, +1 author W Plunkett
  • Published 1992 in Cancer research
Our previous work has shown that incubation of K562 cells or lymphocytes from patients with advanced chronic lymphocytic leukemia (CLL) with arabinosyl-2-fluoroadenine (F-ara-A) potentiates the rate of arabinosylcytosine 5'-triphosphate (ara-CTP) synthesis during subsequent treatment with arabinosylcytosine (ara-C). To test the biochemical modulation of ara-CTP in a clinical setting, we designed a protocol to administer fludarabine (Fludara, F-ara-AMP) and ara-C in a pharmacologically directed… CONTINUE READING