Fluctuations in phenotypes and genotypes within populations of Pseudomonas aeruginosa in the cystic fibrosis lung during pulmonary exacerbations.

@article{Fothergill2010FluctuationsIP,
  title={Fluctuations in phenotypes and genotypes within populations of Pseudomonas aeruginosa in the cystic fibrosis lung during pulmonary exacerbations.},
  author={Joanne L. Fothergill and Eilidh Mowat and Martin James Ledson and Martin John Walshaw and Craig Winstanley},
  journal={Journal of medical microbiology},
  year={2010},
  volume={59 Pt 4},
  pages={472-81}
}
Chronic respiratory infection by Pseudomonas aeruginosa contributes significantly to the morbidity and mortality associated with cystic fibrosis (CF). Using a series of phenotypic and genotypic tests on collections of 40 isolates per sputum sample, we analysed fluctuations within sputum populations of the P. aeruginosa Liverpool epidemic strain (LES) during pulmonary exacerbations. For each of three patients, three sequential sputum samples were analysed: (1) on presentation with exacerbation… CONTINUE READING
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