Fluctuation analysis: the effect of plating efficiency


This paper supplements an earlier paper which explained how to calculate the probability distribution of the number of mutants that would be observed in a fluctuation test experiment. The formulas in that work give the distributions to be expected under a wide variety of experimental conditions, but the method it uses when only a fraction of the mutants will produce visible colonies are clumsy and inefficient. Here I describe efficient procedures for dealing with that case, provided that the mutation rate per cell division remains constant during the experiment.

DOI: 10.1007/BF00123984
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@article{Stewart1991FluctuationAT, title={Fluctuation analysis: the effect of plating efficiency}, author={F. M. Stewart}, journal={Genetica}, year={1991}, volume={84}, pages={51-55} }