Highly Influenced

4 Excerpts

- Published 1991 in Genetica

This paper supplements an earlier paper which explained how to calculate the probability distribution of the number of mutants that would be observed in a fluctuation test experiment. The formulas in that work give the distributions to be expected under a wide variety of experimental conditions, but the method it uses when only a fraction of the mutants will produce visible colonies are clumsy and inefficient. Here I describe efficient procedures for dealing with that case, provided that the mutation rate per cell division remains constant during the experiment.

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@article{Stewart1991FluctuationAT,
title={Fluctuation analysis: the effect of plating efficiency},
author={F. M. Stewart},
journal={Genetica},
year={1991},
volume={84},
pages={51-55}
}