Fluctuating and diffusion-limited hypoxia in hypoxia-induced metastasis.

  title={Fluctuating and diffusion-limited hypoxia in hypoxia-induced metastasis.},
  author={Einar K. Rofstad and Kanthi Galappathi and Berit S. Mathiesen and Else-Beate M Ruud},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={13 7},
PURPOSE Most tumors develop regions with hypoxic cells during growth, owing to permanent limitations in oxygen diffusion (chronic or diffusion-limited hypoxia) and/or transient limitations in blood perfusion (acute or fluctuating hypoxia). The aim of this study was to investigate the relative significance of chronic and acute hypoxia in the development of metastatic disease. EXPERIMENTAL DESIGN D-12 and R-18 human melanoma xenografts were used as models of human cancer. D-12 tumors… CONTINUE READING


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