Fluconazole resistance in Candida glabrata.


We report a case of infection with Candida glabrata in which the organism became resistant to fluconazole and in which pre- and posttreatment isolates were available for comparison. The organism was cross-resistant to ketoconazole and itraconazole, in common with other azole-resistant yeasts. Fluconazole was a potent inhibitor of cytochrome P-450-dependent 14 alpha-sterol demethylase (P-450DM) in lysates of cells from both susceptible and resistant cultures (50% inhibitory concentration, 0.2 microM), indicating that resistance was unrelated to changes in P-450DM. Instead, it appeared to arise from a permeability barrier to fluconazole, since resistant cells were unable to take up radiolabelled drug.

Citations per Year

886 Citations

Semantic Scholar estimates that this publication has 886 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Warnock1988FluconazoleRI, title={Fluconazole resistance in Candida glabrata.}, author={David Warnock and Jillian Burke and Neisha J. Cope and Eugene Malcolm Johnson and N A von Fraunhofer and Evelyn Webb Williams}, journal={Antimicrobial agents and chemotherapy}, year={1988}, volume={37 9}, pages={1962-5} }