Fluconazole resistance in Candida glabrata.

Abstract

We report a case of infection with Candida glabrata in which the organism became resistant to fluconazole and in which pre- and posttreatment isolates were available for comparison. The organism was cross-resistant to ketoconazole and itraconazole, in common with other azole-resistant yeasts. Fluconazole was a potent inhibitor of cytochrome P-450-dependent 14 alpha-sterol demethylase (P-450DM) in lysates of cells from both susceptible and resistant cultures (50% inhibitory concentration, 0.2 microM), indicating that resistance was unrelated to changes in P-450DM. Instead, it appeared to arise from a permeability barrier to fluconazole, since resistant cells were unable to take up radiolabelled drug.

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@article{Warnock1988FluconazoleRI, title={Fluconazole resistance in Candida glabrata.}, author={David Warnock and Jillian Burke and Neisha J. Cope and Eugene Malcolm Johnson and N A von Fraunhofer and Evelyn Webb Williams}, journal={Antimicrobial agents and chemotherapy}, year={1988}, volume={37 9}, pages={1962-5} }