Fluconazole assists berberine to kill fluconazole-resistant Candida albicans.

@article{Li2013FluconazoleAB,
  title={Fluconazole assists berberine to kill fluconazole-resistant Candida albicans.},
  author={Dr Tiebei Li and Yi Xu and Da-zhi Zhang and Hua Quan and Eleftherios Mylonakis and Dan-Dan Hu and Ming-Bang Li and Lan-Xue Zhao and Liang-Hua Zhu and Yan Wang and Yuanying Jiang},
  journal={Antimicrobial agents and chemotherapy},
  year={2013},
  volume={57 12},
  pages={
          6016-27
        }
}
It was found in our previous study that berberine (BBR) and fluconazole (FLC) used concomitantly exhibited a synergism against FLC-resistant Candida albicans in vitro. The aim of the present study was to clarify how BBR and FLC worked synergistically and the underlying mechanism. Antifungal time-kill curves indicated that the synergistic effect of the two drugs was BBR dose dependent rather than FLC dose dependent. In addition, we found that BBR accumulated in C. albicans cells, especially in… CONTINUE READING
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