Flubendazole metabolism and biotransformation enzymes activities in healthy sheep and sheep with haemonchosis.

@article{Brtkov2010FlubendazoleMA,
  title={Flubendazole metabolism and biotransformation enzymes activities in healthy sheep and sheep with haemonchosis.},
  author={Hana B{\'a}rt{\'i}kov{\'a} and Veronika Kr{\'i}zov{\'a} and J{\'i}r{\'i} Lamka and Vladim{\'i}r Kub{\'i}{\vc}ek and Lenka Sk{\'a}lov{\'a} and Barbora Szot{\'a}kov{\'a}},
  journal={Journal of veterinary pharmacology and therapeutics},
  year={2010},
  volume={33 1},
  pages={56-62}
}
The aim of this project was to study the influence of haemonchosis, a common parasitic infection of small ruminants caused by Haemonchus contortus, on the activity of biotransformation enzymes and on in vitro flubendazole (FLU) biotransformation in liver and small intestine of lambs (Ovis aries). Twelve lambs were divided into three groups: non-infected animals, animals orally infected with larvae of H. contortus ISE strain for 7 weeks and for 11 weeks. At the end of the experiment, hepatic and… CONTINUE READING