Flt3 tandem duplication mutations cooperate with Wnt signaling in leukemic signal transduction.

  title={Flt3 tandem duplication mutations cooperate with Wnt signaling in leukemic signal transduction.},
  author={L. Tickenbrock and J. Schwaeble and Markus Wiedehage and B. Steffen and B. Sargin and C. Choudhary and C. Brandts and W. Berdel and C. M{\"u}ller-Tidow and H. Serve},
  volume={105 9},
  • L. Tickenbrock, J. Schwaeble, +7 authors H. Serve
  • Published 2005
  • Biology, Medicine
  • Blood
  • Activating Flt3 mutations occur in about 30% of patients with acute myeloid leukemia (AML), often as in-frame internal tandem duplication (ITD) at the juxtamembrane domain of the receptor. These mutations transform hematopoietic cell lines and primary mouse bone marrow. Here, we analyzed the interaction between oncogenic Flt3-ITD mutations and the Wingless-type (Wnt) signaling pathway in the myeloid progenitor cell line 32D. Microarray analyses revealed higher mRNA expression of Frizzled-4, a… CONTINUE READING
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