Flt3-L gene therapy enhances immunocytokine-mediated antitumor effects and induces long-term memory

Abstract

Therapeutic treatment with hu14.18-IL-2 immunocytokine (IC) or Flt3-L (FL) protein is initially effective at resolving established intradermal NXS2 neuroblastoma tumors in mice. However, many treated animals develop recurrent disease. We previously found that tumors recurring following natural killer (NK) mediated IC treatment show augmented MHC class I… (More)
DOI: 10.1007/s00262-007-0320-5

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@article{Neal2007Flt3LGT, title={Flt3-L gene therapy enhances immunocytokine-mediated antitumor effects and induces long-term memory}, author={Zane C. Neal and Paul M. Sondel and Mary Kay Bates and Stephen D Gillies and Hans Herweijer}, journal={Cancer Immunology, Immunotherapy}, year={2007}, volume={56}, pages={1765-1774} }