Flt-1-Dependent Survival Characterizes the Epithelial-Mesenchymal Transition of Colonic Organoids

@article{Bates2003Flt1DependentSC,
  title={Flt-1-Dependent Survival Characterizes the Epithelial-Mesenchymal Transition of Colonic Organoids},
  author={Richard C. Bates and Jeffrey D. Goldsmith and Robin E. Bachelder and Courtney Brown and Masabumi Shibuya and P. Oettgen and Arthur M Mercurio},
  journal={Current Biology},
  year={2003},
  volume={13},
  pages={1721-1727}
}
Aberrant cell survival and resistance to apoptosis are hallmarks of tumor invasion and progression to metastatic disease, but the mechanisms involved are poorly understood. The epithelial-mesenchymal transition (EMT), a process that facilitates progression to invasive cancer, provides a superb model for studying such survival mechanisms. Here, we used a unique spheroid culture system that recapitulates the structure of the colonic epithelium and undergoes an EMT in response to cytokine… CONTINUE READING

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