Flt-1, but not Flk-1 mediates hyperpermeability through activation of the PI3-K/Akt pathway.

@article{Vogel2007Flt1BN,
  title={Flt-1, but not Flk-1 mediates hyperpermeability through activation of the PI3-K/Akt pathway.},
  author={Carsten Vogel and Alexander Bauer and Marion Wiesnet and Klaus Theo Preissner and Wolfgang Schaper and Hugo H. Marti and Silvia Fischer},
  journal={Journal of cellular physiology},
  year={2007},
  volume={212 1},
  pages={236-43}
}
Vascular endothelial growth factor (VEGF), a potent mediator of endothelial proliferation and migration, has an important role also in brain edema formation during hypoxia and ischemia. VEGF binds to the tyrosine kinase receptors Flt-1 and Flk-1. Yet, their relative importance for hypoxia-induced hyperpermeability is not well understood. We used an in vitro blood-brain barrier (BBB) model consisting of porcine brain microvascular endothelial cells (BMEC) to determine the role of Flt-1 in VEGF… CONTINUE READING

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