FlowClus: efficiently filtering and denoising pyrosequenced amplicons

Abstract

Reducing the effects of sequencing errors and PCR artifacts has emerged as an essential component in amplicon-based metagenomic studies. Denoising algorithms have been designed that can reduce error rates in mock community data, but they change the sequence data in a manner that can be inconsistent with the process of removing errors in studies of real… (More)
DOI: 10.1186/s12859-015-0532-1

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