Flow regulation of vascular tone. Its sensitivity to changes in sodium and calcium.

@article{Bevan1993FlowRO,
  title={Flow regulation of vascular tone. Its sensitivity to changes in sodium and calcium.},
  author={John Althorp Bevan},
  journal={Hypertension},
  year={1993},
  volume={22 3},
  pages={
          273-81
        }
}
Our hypothesis is that flow-through hydraulic drag or shear stresses the extracellular elements in the vascular wall. When the endothelium is intact, this results in the release of endothelium-derived relaxing factor and other substances, eg, prostanoids, from the endothelium. As in some reports, after inhibition of nitric oxide synthase, flow effects are still observed although diminished; the shear effect is extended mechanically to the subendothelial tissues. Shear causes conformational… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 63 REFERENCES

Extracellular sodium modulates flow and stretch-induced constriction in opposite directions

D Henrion, A Klaasen, JA. Bevan
  • FASEB J. 1992;6:A1545. Abstract
  • 1992

Transmembrane signalling by integrins

MA Schartz
  • Trends Cell Biol
  • 1992
VIEW 1 EXCERPT

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