Flow-mediated dilation: just a marker of local shear stress?

  title={Flow-mediated dilation: just a marker of local shear stress?},
  author={Mart{\'i}n Laclaustra and Juan Carlos Kaski and Alejandro Federico Frangi},
  volume={45 3},
  pages={e11-2; author reply e11-2}
Local Shear Stress? To the Editor: We read with interest the article by Mitchell et al1 and agree that flow-mediated dilation (FMD%) response may be partially explained by shear stress (diastolic shear stress [DSS]) or flow changes.2 However, this does not necessarily mean that risk factors do not influence the vascular response. Indeed, Megnien et al3 showed that shear stress reduction provokes different diameter changes in hypercholesterolemic compared with normal subjects. Moreover… CONTINUE READING