Flow inhibits inward remodeling in cannulated porcine small coronary arteries.

  title={Flow inhibits inward remodeling in cannulated porcine small coronary arteries.},
  author={Adrian Pistea and Erik N. T. P. Bakker and Jos A. E. Spaan and Ed Vanbavel},
  journal={American journal of physiology. Heart and circulatory physiology},
  volume={289 6},
The mechanisms of flow-induced vascular remodeling are poorly understood, especially in the coronary microcirculation. We hypothesized that application of flow in small coronary arteries in organoid culture would cause a nitric oxide (NO)-mediated dilation and inhibit inward remodeling. We developed an organoid culture setup to drive a flow through cannulated arterioles at constant luminal pressure via a pressure gradient between the pipettes. Subepicardial porcine coronary arterioles with… CONTINUE READING


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