Flow inhibits inward remodeling in cannulated porcine small coronary arteries.

@article{Pistea2005FlowII,
  title={Flow inhibits inward remodeling in cannulated porcine small coronary arteries.},
  author={Adrian Pistea and Erik N. T. P. Bakker and Jos A. E. Spaan and Ed Vanbavel},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2005},
  volume={289 6},
  pages={H2632-40}
}
The mechanisms of flow-induced vascular remodeling are poorly understood, especially in the coronary microcirculation. We hypothesized that application of flow in small coronary arteries in organoid culture would cause a nitric oxide (NO)-mediated dilation and inhibit inward remodeling. We developed an organoid culture setup to drive a flow through cannulated arterioles at constant luminal pressure via a pressure gradient between the pipettes. Subepicardial porcine coronary arterioles with… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 20 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 39 references

Shear stress attenuates inward remodeling in cultured arteries and requires nitric oxide (Abstract)

  • R Looft-Wilson, SS Segal, WC. Sessa
  • FASEB J 19 Suppl:
  • 2005
1 Excerpt

Calcium blockade prevents pressure-dependent inward remodeling in isolated sub-endocardial resistance vessels (Abstract)

  • O Sorop, EN Bakker, JA Spaan, E. VanBavel
  • FASEB J 18 Suppl:
  • 2004
2 Excerpts

Similar Papers

Loading similar papers…