Flow induces epithelial-mesenchymal transition, cellular heterogeneity and biomarker modulation in 3D ovarian cancer nodules.

@article{Rizvi2013FlowIE,
  title={Flow induces epithelial-mesenchymal transition, cellular heterogeneity and biomarker modulation in 3D ovarian cancer nodules.},
  author={Imran Rizvi and Umut A. Gurkan and Savas Tasoglu and Nermina Alagic and Jonathan P. Celli and Lawrence B Mensah and Zhiming Mai and Utkan Demirci and Tayyaba Hasan},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 22},
  pages={E1974-83}
}
Seventy-five percent of patients with epithelial ovarian cancer present with advanced-stage disease that is extensively disseminated intraperitoneally and prognosticates the poorest outcomes. Primarily metastatic within the abdominal cavity, ovarian carcinomas initially spread to adjacent organs by direct extension and then disseminate via the transcoelomic route to distant sites. Natural fluidic streams of malignant ascites triggered by physiological factors, including gravity and negative… CONTINUE READING
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