Flow-induced vascular remodeling in the mouse: a model for carotid intima-media thickening.

@article{Korshunov2003FlowinducedVR,
  title={Flow-induced vascular remodeling in the mouse: a model for carotid intima-media thickening.},
  author={Vyacheslav A. Korshunov and Bradford C. Berk},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2003},
  volume={23 12},
  pages={2185-91}
}
OBJECTIVE Vascular remodeling of the carotid artery with intima-media thickness (IMT) is an important predictive factor for human cardiovascular disease. We characterized a mouse model of vascular remodeling. METHODS AND RESULTS The left external and internal carotid branches were ligated so that left carotid blood flow was reduced to flow via the occipital artery. In response to partial ligation of the left carotid artery (LCA), blood flow significantly decreased (-90%) in the LCA and… CONTINUE READING

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