Flow-induced protein kinase A–CREB pathway acts via BMP signaling to promote HSC emergence

Abstract

Fluid shear stress promotes the emergence of hematopoietic stem cells (HSCs) in the aorta-gonad-mesonephros (AGM) of the developing mouse embryo. We determined that the AGM is enriched for expression of targets of protein kinase A (PKA)-cAMP response element-binding protein (CREB), a pathway activated by fluid shear stress. By analyzing CREB genomic… (More)
DOI: 10.1084/jem.20141514

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