Flow-induced constriction in arterioles of hyperhomocysteinemic rats is due to impaired nitric oxide and enhanced thromboxane A(2) mediation.

@article{Bagi2001FlowinducedCI,
  title={Flow-induced constriction in arterioles of hyperhomocysteinemic rats is due to impaired nitric oxide and enhanced thromboxane A(2) mediation.},
  author={Zsolt Bagi and Zoltan Ungvari and Lajos Szoll{\'a}r and A. E. Koller},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2001},
  volume={21 2},
  pages={233-7}
}
Hyperhomocysteinemia (HHcy) is thought to promote arteriosclerosis and peripheral arterial disease, in part by impairing the function of endothelium. Because flow-induced dilation is mediated by the endothelium, we hypothesized that HHcy alters this response by interfering with the synthesis/action of NO and prostaglandins. Thus, changes in the diameter of isolated, pressurized (at 80 mm Hg) gracilis skeletal muscle arterioles (diameter approximately 170 microm) from control and methionine diet… CONTINUE READING
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