Flow-induced [Ca2+]i increase depends on nucleotide release and subsequent purinergic signaling in the intact nephron.

@article{Jensen2007FlowinducedI,
  title={Flow-induced [Ca2+]i increase depends on nucleotide release and subsequent purinergic signaling in the intact nephron.},
  author={Mikkel Erik Juul Jensen and Elvin Odgaard and Mette H\ogh Christensen and Helle A Praetorius and Jens Leipziger},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2007},
  volume={18 7},
  pages={2062-70}
}
Flow induces cytosolic Ca(2+) increases ([Ca(2+)](i)) in intact renal tubules, but the mechanism is elusive. Mechanical stimulation in general is known to promote release of nucleotides (ATP/UTP) and trigger auto- and paracrine activation of P2 receptors in renal epithelia. It was hypothesized that the flow-induced [Ca(2+)](i) response in the renal tubule involves mechanically stimulated nucleotide release. This study investigated (1) the expression of P2 receptors in mouse medullary thick… CONTINUE READING

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