Flow-dependent remodeling of small arteries in mice deficient for tissue-type transglutaminase: possible compensation by macrophage-derived factor XIII.

@article{Bakker2006FlowdependentRO,
  title={Flow-dependent remodeling of small arteries in mice deficient for tissue-type transglutaminase: possible compensation by macrophage-derived factor XIII.},
  author={Erik N. T. P. Bakker and Adrian Pistea and Jos A. E. Spaan and Titia M Rolf and Carlie JM de Vries and Nico van Rooijen and Eleonara Candi and Ed Vanbavel},
  journal={Circulation research},
  year={2006},
  volume={99 1},
  pages={86-92}
}
Chronic changes in blood flow induce an adaptation of vascular caliber. Thus, arteries show inward remodeling after a reduction in blood flow. We hypothesized that this remodeling depends on the crosslinking enzyme tissue-type transglutaminase (tTG). Flow-dependent remodeling was studied in wild-type (WT) and tTG-null mice using a surgically imposed change in blood flow in small mesenteric arteries. WT mice showed inward remodeling after 2 days of low blood flow, which was absent in arteries… CONTINUE READING

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