Flow-dependent remodeling in the carotid artery of fibroblast growth factor-2 knockout mice.

@article{Sullivan2002FlowdependentRI,
  title={Flow-dependent remodeling in the carotid artery of fibroblast growth factor-2 knockout mice.},
  author={Chris J Sullivan and James B. Hoying},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2002},
  volume={22 7},
  pages={1100-5}
}
OBJECTIVE Fibroblast growth factor-2 (FGF2) has been implicated as a mediator in the structural remodeling of arteries. Chronic changes in blood flow are known to cause reorganization of the vessel wall, resulting in permanent changes in artery size (flow-dependent remodeling). Using FGF2 knockout (Fgf2(-/-)) mice, we tested the hypothesis that FGF2 is required during flow-dependent remodeling of the carotid arteries. METHODS AND RESULTS All branches originating from the left common carotid… CONTINUE READING

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