Flow-dependent Smad2 phosphorylation and TGIF nuclear localization in human aortic endothelial cells.

@article{Shepherd2011FlowdependentSP,
  title={Flow-dependent Smad2 phosphorylation and TGIF nuclear localization in human aortic endothelial cells.},
  author={Robert D. Shepherd and Stephanie M Kos and Kristina D Rinker},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2011},
  volume={301 1},
  pages={H98-H107}
}
Endothelial cells respond to fluid flow stimulation through transient and sustained signal pathway activation. Smad2 is a signaling molecule and transcription factor in the Smad signaling pathway, traditionally associated with TGF-β. Although phosphorylation of Smad2 in the receptor-dependent COOH-terminal region is the most appreciated way Smad2 is… CONTINUE READING