Flow cytometry of p53 protein expression in some hematological malignancies.

  title={Flow cytometry of p53 protein expression in some hematological malignancies.},
  author={E Kon{\'i}kov{\'a} and J Kusenda and Ol'ga Babus{\'i}kov{\'a}},
  volume={46 6},
p53 is a tumor suppressor gene encoding a nuclear phosphoprotein that plays an important role in the control of normal cell proliferation. We have tried to establish the value of the p53 protein expression in peripheral blood (PB) and/or bone marrow (BM) cells of patients with some hematological malignancies. A recently developed fixation/permeabilization method was modified for flow cytometric assessment of p53 protein expression using two anti-p53 monoclonal antibodies. p53 quantitation… CONTINUE READING


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