Flow cytometry of breast carcinoma: I. Relation of DNA ploidy level to histology and estrogen receptor.

@article{Olszewski1981FlowCO,
  title={Flow cytometry of breast carcinoma: I. Relation of DNA ploidy level to histology and estrogen receptor.},
  author={Włodzimierz Olszewski and Zbigniew Darzynkiewicz and Paul Peter Rosen and Morton K. Schwartz and Myron R. Melamed},
  journal={Cancer},
  year={1981},
  volume={48 4},
  pages={980-4}
}
Flow cytometry studies of the DNA distribution of tumor cells from 92 human breast cancers showed measurable aneuploidy (hyperploidy) in 83 cases (92%). The DNA ploidy values were unimodal in each case, but there was a bimodal distribution for the entire series. One group of tumors had a diploid or near diploid DNA distribution and a second group had ploidy levels from triploid to tetraploid or higher. The tumors with lower DNA ploidy (at or near diploid) tended to be histologically low grade… CONTINUE READING

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